Peers backed an amendment to the Health and Social Care Bill - demanding mental health is made a higher priority - by a margin of four votes.
Several other amendments were debated on Wednesday, but none were voted upon.
Earlier, David Cameron rebuffed calls to drop the bill entirely, but Labour leader Ed Miliband described it as a "complete disaster".
The Health and Social Care Bill, which introduces the biggest shake-up since the founding of the NHS in 1948 and would put GPs in control of much of the NHS budget, returned to the Lords on Wednesday.
The legislation is opposed by Labour and has come under fire from several Liberal Democrat and independent peers, meaning it could have a difficult time getting through Parliament.
'Opportunists'The government has offered more than 100 concessions in an effort to get the bill passed, but opponents say it should be dropped in its entirety.
Several peers from across the political spectrum have proposed their own amendments too. These will be discussed over the next few weeks.
Continue reading the main story The Health and Social Care Bill is one of the flagship bits of legislation from the Conservative-Lib Dem coalition governmentGPs and other clinicians will be given much more responsibility for NHS spending in England and greater competition with the private sector encouragedThe plans were put on hold last Spring after opposition from MPs and peers - Labour warned of privatisation at the expense of patient care.After a "listening exercise" some changes were made and the revised bill cleared its next Commons stageBut when the bill was in the Lords before Christmas it faced mounting opposition and the royal colleges of nurses and midwives joined those who opposed the bill outright.Labour are calling for the bill to be dropped, but a series of fresh amendments have been put forward aimed at tackling critics' concerns. They start being debated in the Lords today.There have been reports No 10 want to axe Health Sec Andrew Lansley for mishandling the bill, but they have been denied and David Cameron has insisted the bill is needed to improve the NHS.The first of those debated on Wednesday - demanding that the health secretary ensures that mental health care is treated as importantly as physical health care by the NHS - was put forward by Labour's Lord Patel, and passed by a by 244 votes to 240.Three Liberal Democrats - Lord Alliance, Lord Carlile of Berriew and Baroness Tonge - rebelled against the government.
Peers accepted a government-backed amendment specifying that the health secretary retains "ministerial responsibility to Parliament for the provision of the health service in England".
Several more amendments - all discussing the powers and responsibilities of the health secretary - were debated.
Opposition to the bill from medical professionals - including the British Medical Association and the Royal College of Nursing - has led to speculation about Health Secretary Andrew Lansley's position.
At prime minister's questions in the House of Commons, Mr Miliband told Mr Cameron: "You know, in your heart of hearts, this is a complete disaster, this bill."
Referring to a critical article on the Tory Reform Group website saying: "It comes to something when even the Tories don't trust the Tories on the NHS."
He said the prime minister had broken a pre-election promise not to have any "top-down re-organisation of the NHS" and told him: "Every day he fights for this bill, every day trust in him on the NHS ebbs away, every day it becomes clearer the NHS is not safe in his hands."
But Mr Cameron said Labour had previously supported NHS reform - and would not match government commitments on NHS spending: "They are not in favour of the money. They are not in favour of the reform. They are just a bunch of opportunists."
He criticised Labour's record on the NHS in Wales - where the party controls the Welsh Assembly - and said the coalition was cutting bureaucracy and ploughing money back into patient care.
He said of Mr Miliband: "This is not a campaign to save the NHS. This is a campaign to try and save his leadership. I make this prediction, the NHS will go on getting better and his prospects will go on getting worse."
'Squeezing out' patientsThe Tory Reform Group later accused Mr Miliband of a "complete misrepresentation" of its position - as the blog post had been written by an independent contributor and it said it remained a "staunch supporter" of the proposals.
As the session was under way in the Commons, the Faculty of Public Health became the latest healthcare body to call for the Bill to be dropped, "in the best interests of everyone's health".
But 54 NHS Trust directors have backed the plan in a letter to the Times, saying there are "sound medical and clinical reasons" for it.
On Tuesday Downing Street said Mr Lansley had the prime minister's "full support" - following an anonymous quote in the Times, attributed to a Downing Street source, suggesting the health secretary should be "taken out and shot" over the policy.
It was even suggested that the former Labour Health Secretary Alan Milburn might be given a peerage and then take over from Mr Lansley.
But Mr Milburn told BBC Radio 4's World at One there was "fat chance" of that happening.
He added: "There might be a demand side. You'll have to ask Number 10 about that. But there certainly isn't a supply side, at least as not as far as I'm concerned."
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